Recent Publications

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2013
Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function.

S. Armando Villalta, Jiena Lang, Samantha Kubeck, Beniwende Kabre, Gregory L. Szot, Boris Calderon, Clive Wasserfall, Mark A. Atkinson, Rolf A. Brekken, Nick Pullen,5 Robert H. Arch, and Jeffrey A. Bluestone.

Diabetes (in press)

2013
The b7-independent isoform of ctla-4 functions to regulate autoimmune diabetes.

Stumpf M, Zhou X, Bluestone JA.

J Immunol; 190(3):961-9.

2013
DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability.

Jeker LT, Zhou X, Blelloch R, Bluestone JA.

PLoS One; 8(5).

2013
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

Herold KC, Vignali DA, Cooke A, Bluestone JA.

Nat Rev Immunol; 13(4):243-56.

2013
Cell-Based Therapeutics: The Next Pillar of Medicine.

Michael A. Fischbach, Jeffrey A. Bluestone, and Wendell A. Lim.

Sci Transl Med; 5(179): 1-7.

2013
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.

Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA.

J Exp Med; 209(10):1713-22.

2012
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.

Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H.

Proc Natl Acad Sci U S A; 109(31):12668-73.

2012
MicroRNA 10a marks regulatory T cells.

Jeker LT, Zhou X, Gershberg K, de Kouchkovsky D, Morar MM, Stadthagen G, Lund AH, Bluestone JA.

PLoS One; 7(5).

2012
A resource for the conditional ablation of microRNAs in the mouse.

Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT.

Cell Rep; 1(4):385-91.

2012
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM.

J Immunol; 186(7):3918-26.

2011
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.

Penaranda C, Tang Q, Bluestone JA.

J Immunol; 187(4):2015-22.

2011
Type 1 diabetes immunotherapy: is the glass half empty or half full?

Herold KC, Bluestone JA.

Sci Transl Med; 3(95):95fs1.

2011
The yin and yang of interleukin-2-mediated immunotherapy.

Bluestone JA.

N Engl J Med; 365(22):2129-31.

2011
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.

Penaranda C, Tang Q, Ruddle NH, Bluestone JA.

Diabetes; 59(6):1461-8.

2010
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA.

PLoS One; 5(7):e11726.

2010
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

Melton AC*, Bailey-Bucktrout SL*, Travis MA, Fife BT, Bluestone JA, Sheppard D. *contributed equally

J Clin Invest; 120(12):4436-44.

2010
Genetics, pathogenesis and clinical interventions in type 1 diabetes.

Bluestone JA, Herold K, Eisenbarth G.

Nature; 464(7293):1293-300.

2010
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Xuyu Zhou, Samantha Bailey-Bucktrout, Lukas T. Jeker, Cristina Penaranda, Marc Martínez-Llordella, Meredith Ashby, Maki Nakayama, Wendy Rosenthal and Jeffrey A. Bluestone

Nat Immunol; 10(9):1000-7.

2009
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA.

Nat Immunol; 10(11):1185-92.

2009
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA.

J Exp Med; 206(3):507-14.

2009
Expansion of human regulatory T-cells from patients with type 1 diabetes.

Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA.

Diabetes; 58(3):652-62.

2009
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.

Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA.

J Exp Med; 205(9):1983-91.

2008
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA.

Immunity; 28(5):687-97.

2008

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